Syntheses and Characterizations of Smart and Biodegradable Dendritic Nanoparticles for Controlled Drug Delivery

In order to transport therapeutic agents across blood brain barrier (BBB) for sustained time in response to biological need, we designed and synthesized novel dendritic nanoparticles with thermoresponsive and biodegradable properties as drug delivery systems. The nano-sized dendrimer was prepared by coupling reaction of poly(L-lysine) (PLL) dendron and poly(Nisopropylacrylamide) (PNIPAAM) grafted with poly(L-lactic acid) (PLLA). The chemical structure and molar mass of the dendrimer was characterized and confirmed by fourier transform infrared spectroscopy (FTIR) and matrix assisted laser desorption/ionization time of flight mass spectroscopy (MALDI-TOF). The dendrimer was responsive to temperature changes by showing lower critical solution temperature (LCST) measured by UV-VIS spectroscopy. The LCST depended on the concentrations of the dendrimer. The dendrimer also demonstrated biodegradable properties with decreasing their molar mass as a function of time.